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  Laura M Richter
  President and CEO
  30 East 72nd Street
  Suite 16
  New York, NY
  10021 U.S.A.

  Mailing Address:
  78 Saint Moritz Dr
  Erial, NJ 08081 U.S.A.

  Tel: 212 452 1231
  Fax: 212 452 1231
  Email: ipif@ipif.org

  Susanne Bross Emmerich
  Founder

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  IP WORLD Community Group

  Incontinentia Pigmenti International Foundation



WHAT GOES WRONG IN INCONTINENTIA PIGMENTI?
Males with cannot survive without a functioning NEMO gene, and thus die in utero. In females, some cells have a normal functioning NEMO gene (from the normal X chromosome) while other cells have a defective NEMO gene. Currently, it is thought that the symptoms of IP in females result from cells with a defective NEMO gene in the affected tissue. Now that the gene has been found, this view can be tested.

The normal function of NEMO is to allow cells to respond to outside signals, such as growth factors. Follow this link to read more technical information on NEMO with links to references and DNA and protein sequence.

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